Other name :Acetyl Hexapeptide-38/Acetyl Hexapeptide-38/Breast Enhancement Peptide/Adifyline/Acetyl Hexapeptide- Acetyl Hexapeptide-38

Amino acid sequence: Asp-Ser-Val-Val-Val-Arg-Thr-NH₂

Molecular formula: C₃₀H₅₆N₁₀O₉

Molecular weight: 700.41 g/mol

Appearance: White to off-white powder (lyophilized powder) / Colorless transparent liquid (solution type)

Solubility: Water-soluble

pH range: 4.0 to 7.0

Purity ≥95% (HPLC)

Storage Conditions: Lyophilized powder: Store sealed and protected from light at 2–8°C; shelf life: 2 years; Solution: Store at 2–8°C; shelf life: 18 months.

Package:100g per bag or bottle

Quality validity: 2 years

MOQ 100G

Core Efficacy

Promotes fat deposition for localized volume enhancement and body contouring

This represents the most fundamental differentiated efficacy of acetylhexapeptide-38.By activating the expression of PGC-1α (peroxisome proliferator-activated receptor γ coactivator 1α), it achieves a upregulation of up to 61.1%, promotes the differentiation of pre-adipocytes into mature adipocytes, increases intracellular lipid content by 32.4%, thereby enhancing the volume of subcutaneous adipose tissue in specific areas (e.g., chest, buttocks, cheeks, lips) and achieving a non-invasive "plumping and shaping" effect.

Promotes collagen synthesis, anti-aging, and skin tightening

Acetylhexapeptide-38 can activate the TGF-β signaling pathway, promote the production of type I and type III collagen, increase dermal thickness, improve skin elasticity and firmness, and reduce wrinkle depth.

Blend dynamic wrinkles with expression lines

By mildly inhibiting the formation of SNARE complexes and reducing neurotransmitter release, it softens dynamic expression lines (such as crow's feet and forehead wrinkles) caused by repetitive muscle movements, operating through a mechanism similar to a mild version of "topical botulinum toxin."

Repair the skin barrier

Promotes the production of stratum corneum lipids (such as ceramides), strengthens the dermo-epidermal junction (DEJ), reduces transepidermal water loss (TEWL), and enhances skin hydration capacity.

Highly safe, mild and non-irritating

It has a comedogenicity rating of 0, contains no irritating chemicals, and is suitable for all skin types including sensitive skin.It has been included in both the Japanese Cosmetic Ingredients Database (JSCI) and the European Union Cosmetic Ingredients Database.

Reference proportions for addition to cosmetics

Lyophilized powder (raw material powder)

Clinical data support

In vitro experiment: After 10 days of treatment with 0.5 mg/mL acetyl hexapeptide-38 in preadipocytes, PGC-1 α expression increased by 61.1% and fat accumulation increased by 32.4%

Human clinical study: 30 women (25-45 years old) were treated with a cream containing 500 ppm acetylhexapeptide-38 twice daily, starting to take effect in the second week. In the eighth week, the fat volume of the treatment group increased by 30 times compared to the placebo group

Double blind trial: After using 2% concentration for 56 days, fat volume increased by 18% and lip plumpness score improved by 22% (n=87)

Formula precautions

Addition timing: Add in the final stage of cosmetics production (low-temperature stage), with a temperature not exceeding 40-45 ℃

PH range: It is recommended to control the pH of the formula between 5.0 and 7.0

Compatibility: Good compatibility, stable without discoloration; Can be used in combination with hyaluronic acid, niacinamide, vitamin C/E, collagen peptides, etc

Compatibility taboos: Avoid using high concentrations of strong acid components such as fruit acid and salicylic acid at the same time to prevent damage to peptide activity

Applicable products: facial plump products, breast/hip plump cream, lip plump products, facial anti-aging essence, eye cream, hand cream, mature women's makeup, etc