Composition: Palmitoyl tripeptide-1 (Pal-GHK) + Palmitoyl tetrapeptide-7 (Pal-GQPR)

Palmitoyl tripeptide-1 CAS number 147732-56-7

A complex (Tripeptide-1 + Tetrapeptide-7) used for anti-aging

Palmitoyl tetrapeptide-7 CAS number 221227-05-0

The palmitoyl tripeptide sequence is Pal-Gly-His-Lys (palmitoyl-glycine-histidine-lysine).

The palmitoyl tetrapeptide sequence is Pal-Gly-Gln-Pro-Arg (palmitoyl-glycine-glutamine-proline-arginine).

Palmitoyl tripeptide-1 has a molecular weight of 578.79 g/mol

Palmitoyl tetrapeptide-7: Molecular weight 694.9 g/mol

Appearance (solution form): Colorless to faint yellow transparent liquid

Appearance (oil-soluble formulation): Colorless oil solution (Matrixyl 3000 OS)

Solubility: Water-soluble (Standard Edition) / Oil-soluble (OS Edition)

pH range: 5.0 to 7.0

MOQ: 100grams

Package: 100grams/bottle, 1kg/bag

Storage：Store in a cool 2-8 degree, dry place and keep tightly sealed.

Note: Matrixyl 3000 is a compound raw material and does not have an independent CAS number.The solution-type INCI name is: glycerol, water, butanediol, carbomer, polysorbate 20, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7.The actual active peptide concentration is significantly lower than the total solution concentration.

Source of Ingredients and Mechanism of Action

Matrixyl 3000 consists of two signal peptides (Matrikines) that mimic natural peptide fragments produced following skin matrix degradation, thereby sending a "repair" signal to skin cells.

Palmitoyl tripeptide-1 (Pal-GHK): A fragment derived from the α2 chain of human type I collagen that mimics collagen degradation signals and stimulates fibroblasts to synthesize new collagen and glycosaminoglycans.

Palmitoyl tetrapeptide-7 (Pal-GQPR): A natural fragment derived from immunoglobulin IgG with immunomodulatory properties, which protects collagen from degradation by inhibiting the inflammatory cytokine IL-6.

Core Efficacy

Promotes the synthesis of collagen and elastin (key efficacy)

The two peptides act synergistically to significantly promote the synthesis of type I collagen, elastin, and glycosaminoglycans (including hyaluronic acid).In vitro studies demonstrate that Pal-GHK at concentrations of 5–10 ppm can enhance collagen synthesis by up to 350% and polysaccharide synthesis by 46%.

Anti-inflammatory protection and inhibition of collagen degradation

Palmitoyl tetrapeptide-7 reduces inflammation-induced damage to collagen by inhibiting the production of the pro-inflammatory factor IL-6.In vitro experiments demonstrated that IL-6 reduced collagen degradation by 40%–86% (compared to UV radiation control), effectively preserving the existing collagen network.

Significantly reduces wrinkles

Clinical studies have demonstrated that middle-aged and elderly women using a solution containing 3% Matrixyl 3000 experience improvements of 16% to 44% in wrinkle depth, skin roughness, and wrinkle density.Clinical studies have demonstrated a 33% reduction in wrinkle density.

Repair the fibrous network and enhance skin elasticity

It helps reduce fiber fragmentation and supports the reconstruction of the dermal fibrous network in the mastoid region. After 2 months of use, improvement in the fibrous network can reach up to 54%, with significant skin enhancement observed in 71% of volunteers.

Reduce the expression of progerin protein

Recent studies demonstrate that Matrixyl 3000 exhibits regulatory effects on progerin (a denatured product of Lamin A, a marker of aging), reducing its expression and thereby delaying aging at the cellular level.

Promote DEJ thickening

Promotes thickening of the dermo-epidermal junction (DEJ), stimulates regeneration of type I and type VII collagen, and enhances skin thickness, density, and elasticity.

Reference proportions for addition to cosmetics

Soluble raw material (standard version; INCI contains carriers such as glycerol and water)

Note: Efficacy studies were conducted at a 3% concentration; for efficacy claims, an addition level of ≥3% is recommended.The actual final concentration of active peptides is significantly lower than the added amount in solution.

Oil-soluble plate material (Matrixyl 3000 OS)

Applicable Product Types

Anti-aging/anti-wrinkle essence, face cream, emulsion

Tightening and enhancement products (for face, neck, hands)

Eye cream, neck cream

Mask (patch-type/moisturizing type)

Post-repair products for medical art treatments

Photoaging Repair Products

Special care products for mature skin

Formulation Precautions

Administration timing: Add during the final stage of cosmetic production (low-temperature phase), with temperature not exceeding 40°C, and ensure thorough mixing before addition.

pH range: The recommended formulation pH should be controlled between 5.0 and 7.0.

Compatibility: Excellent compatibility, can be used in combination with Argireline (acetylhexapeptide-8), hyaluronic acid, vitamin C, nicotinamide, retinol, and blue copper peptide.

Collaborative Component Recommendation:

Matrixyl 3000 + Argireline (signal peptide + neurotransmitter-inhibiting peptide, dual wrinkle-reducing effect)

Matrixyl 3000 + Hyaluronic Acid (promotes collagen synthesis + provides deep hydration)

Matrixyl 3000 + Vitamin C (for tissue repair and reconstruction + antioxidant brightening effects)

Matrixyl 3000 + Retinol (recommended for separate application in the morning and evening)

Onset time: Significant effects can be observed after regular use for 4–8 weeks; the clinical trial duration typically ranges from 5 to 6 days.

Safety: Mild and non-irritating, suitable for all skin types including sensitive skin; free from parabens and other irritant chemicals.