Aliased names: Hexapeptide, Protein Stability Network Regulator

Amino acid sequence: Phe-Val-Ala-Pro-Phe-Pro (FVAPFP)

Sequence abbreviation: H-Phe-Val-Ala-Pro-Phe-Pro-OH

Molecular weight: 676.8 g/mol

Density: 1.269 ± 0.06 g/cm³ (predicted value)

pKa 3.43 ± 0.20 (predicted value)

Appearance: White to off-white lyophilized powder

Solubility: Water-soluble

Purity ≥95%–98% (HPLC)

Storage Conditions: Lyophilized powder – store sealed and protected from light at 20°C; for short-term storage, keep at 4°C for no more than one week.

Note: Hexapeptide-11 was initially isolated from yeast fermentation broth.Scientists have discovered that individuals engaged in long-term fermentation activities (e.g., in the brewing and dairy industries) exhibit hand skin that is smoother, tighter, and more delicate than that of the general population. Through extensive experimental research, this active polypeptide was ultimately successfully isolated from yeast fermentation broth.

Core Efficacy

Promotes the synthesis of collagen and elastin (core efficacy)

Hexapeptide-11 acts on dermal fibroblasts, upregulating key genes responsible for collagen production, thereby promoting the synthesis of type I collagen, type IV collagen, elastin, and extracellular matrix components (including hyaluronic acid), which contributes to skin tightening and maintenance of skin integrity.

Regulate the Proteostasis Network

Hexapeptide-11 is a protein stabilization network regulator that promotes dose-and time-dependent activation of genes related to the proteasome, autophagy, and molecular chaperones, enhances nuclear accumulation of Nrf2, increases high-expression levels of proteasomal protein subunits and proteasomal peptidase activity, and maintains normal protein folding and degradation within cells.

Antioxidant stress, delaying cellular aging

Enhance the expression of antioxidant genes Nrf2, Keap1, NQO1, and TXNRD1 to protect fibroblasts from premature cellular aging mediated by oxidative stress.By mediating the downregulation of cellular proteins such as ATM (ataxia-telangiectasia mutation protein) and p53, it further protects cell viability.

Promote wound healing and tissue repair

It induces the enzymatic activity of extracellular MMP-2 and MMP-9, thereby promoting wound healing and matrix remodeling.It simultaneously promotes the differentiation and maturation of epidermal cells, demonstrating significant efficacy in post-inflammatory hyperpigmentation repair.

Anti-wrinkle and anti-aging; firming and enhancing skin texture

Through multi-pathway synergistic effects, hexapeptide-11 reduces the formation of fine lines and wrinkles, combats skin laxity, and enhances skin elasticity and firmness.The human skin deformation test has confirmed that hexapeptide-11 can improve skin elasticity.

Gene Chip Validation – Regulation of Six Key Skin Care Genes

After analyzing 22,000 genes in the human genome using gene chip activity detection technology, it was found that hexapeptide-11 can regulate six key skin care genes.

transmembrane protein

Growth Factor

stromatin

Development of skin lipids

Cellular shock/cellular stress

hormonal regulation

Reference proportions for addition to cosmetics

Lyophilized powder (raw material powder)

Applicable Product Types

Anti-aging/anti-wrinkle essence, face cream, lotion

Tightening and enhancing products

Eye cream (for reducing crow's feet and fine lines around the eyes)

Mask (patch-type/moisturizing type)

Pimple scar repair products

Post-repair products for medical art pieces

Photoaging Repair Products

Bath gel and cleansers

Formulation Precautions

Administration timing: Add during the final stage of cosmetic production (low-temperature phase), with temperature not exceeding 40°C, to avoid peptide chain degradation caused by high temperatures.

pH range: The recommended formulation pH should be controlled between 5.0 and 7.0.

Compatibility: exhibits good compatibility and can be formulated with various active ingredients.

Collaborative Component Recommendation:

Hexapeptide-11 + Acetylhexapeptide-8 (Argireline) – signal peptide + neurotransmitter-inhibiting peptide, dual anti-wrinkle agent

Hexapeptide-11 + Palmitoyl tripeptide-1/palmitoyl tetrapeptide-7 (Matrixyl 3000) – a multi-pathway agent promoting collagen synthesis

Hexapeptide-11 + Hyaluronic Acid – Promotes collagen synthesis + provides deep hydration

Hexapeptide-11 + Vitamin C – Anti-aging Repair + Antioxidant Brightening

Safety: Demonstrates no significant toxicity to normal diploid lung or skin fibroblasts, exhibiting high safety profile and broad applicability in skincare products.

Hexapeptide-11 — The Proteostasis Network Modulator from Yeast

A bioactive hexapeptide (Phe-Val-Ala-Pro-Phe-Pro) originally isolated from yeast fermentation extract, functioning as a proteostasis network modulator. It activates dermal fibroblasts to promote collagen I, collagen IV, elastin, and hyaluronic acid synthesis. Gene chip analysis on 22,000 human genes confirms regulation of six key skincare gene categories: transmembrane proteins, growth factors, matrix proteins, skin lipid development, cell stress responses, and hormonal regulation. Also upregulates antioxidant genes Nrf2, Keap1, NQO1, and TXNRD1, and downregulates ATM and p53 to protect fibroblasts from oxidative stress-induced premature senescence. Induces extracellular MMP-2 and MMP-9 activity for wound healing. Non-toxic with high safety profile, suitable for all skin types.