I. Basic Product Information

Chinese name: Tetrapeptide-21 (also known as Tetrascapeptide-21 or GEKG peptide)

English name: Tetrapeptide-21

CAS Number: 960608-17-7

Molecular formula: C15H27N5O7

Molecular weight: 389.4 g/mol

Amino acid sequence: Gly-Glu-Lys-Gly (GEKG)

Specification: White powder (purity typically ≥95%–98%)

Storage conditions: Store sealed and protected from light; refrigeration at 2°C–8°C is recommended. For long-term storage, freeze-drying at –20°C is advised.

Package:100g per bag

MOQ 500G

II. Core Efficacy and Mechanism of Action

Tetrapeptide-21 is a bioinspired tetrapeptide derived from the skin itself, whose amino acid sequence (Gly-Glu-Lys-Gly) replicates portions of various extracellular matrix (ECM) proteins (such as collagen types I–V and elastin).As a leading solution in the field of anti-aging for firming and hydration, its core benefits are primarily manifested in three key aspects:

Powerfully promotes collagen and extracellular matrix (ECM) synthesis: Tetrapeptide-21 specifically binds to the zinc finger structure of matrix metalloproteinase-1 (MMP-1), effectively inhibiting collagen degradation.Simultaneously, it can enhance the expression of genes responsible for collagen synthesis by up to 2.5-fold and promote the synthesis of hyaluronic acid and fibronectin, thereby addressing skin aging at its root cause.

Excellence in firming and wrinkle reduction: By enhancing the synthesis of extracellular matrix in the dermal layer, tetrapeptide-21 significantly improves skin firmness, smoothness, and elasticity.Clinical trials have demonstrated that after 56 days of use of the cream containing 0.01% tetrapeptide-21, facial fish tail wrinkles and fine lines showed significant improvement; in a 12-week human trial, skin elasticity increased by 29% and wrinkle area decreased by 33%.

Deep hydration and volume enhancement: As the content of hyaluronic acid (glycosaminoglycans, GAGs) increases, the skin can bind more water molecules, providing ample hydration, increasing skin volume, and resulting in a fuller, more youthful appearance.

III. Recommended Addition Ratios and Application Scenarios

Tetrapeptide-21 exhibits excellent water solubility, stability in systems with a pH range of 5.3–7.3, good compatibility, and no color change.It is recommended to add it during the final stage of formulation under low-temperature conditions below 40°C.

Daily anti-aging serum/creme: Recommended concentration is 0.01%–0.05% (based on pure powder).As a key anti-aging ingredient in daily skincare routines, its morning and evening application effectively reduces fine wrinkles and enhances skin elasticity.

Special care for the eyes and lips: The recommended concentration is 0.01%–0.02%.For periorbital crow's feet and lip dry lines, it delivers a gentle yet effective tightening and wrinkle-reducing effect.

High-end intensive repair/anti-wrinkle products: Recommended concentration is 0.02%–0.05%.As a high-concentration active ingredient, it effectively addresses deep wrinkles and skin laxity.

IV. Formulation Recommendations and Safety Compliance

Synergistic Gold Combination: It can be formulated with hyaluronic acid and various growth factors (such as fibroblast growth factor [FGF]) to jointly promote fibroblast proliferation and angiogenesis, maximizing anti-aging and reparative effects; it may also be combined with other peptides such as matrixyl to achieve multi-target anti-wrinkle action.

Safety and Compliance: Tetrapeptide-21 is a safe and effective anti-aging ingredient with mild properties, suitable for various anti-wrinkle and anti-aging skincare products, including those for sensitive skin and adult skin care.

Application Scope: In addition to facial skincare products, it is also suitable for anti-aging male care formulations and anti-aging foundation products, effectively improving the overall condition and structure of the skin.