I. Basic Product Information

Chinese name: Hexapeptide-9 (also known as Kelite or Kelis)

English name: Hexapeptide-9

CAS Number: 1228371-11-6

Molecular formula: C₂₄H₃₈N₈O₉

Molecular weight: 582.61 g/mol

Amino acid sequence: H-Gly-Pro-Gln-Gly-Pro-Gln-OH (a repetitive glycine-proline-glutamine sequence)

Specification: White powder (purity ≥98%) or transparent liquid

Solubility: Well soluble in water, and soluble in cosmetic solvents such as glycerol and propylene glycol.

Stability: Stable in formulations with a pH range of 4.0 to 7.0, avoiding strong acidic or alkaline environments.

Storage conditions: Store sealed and protected from light at 2°C to 8°C; for long-term storage, it is recommended to freeze at-20°C.

Package:100g per bag

MOQ 500G

II. Core Efficacy and Mechanism of Action

Hexapeptide-9 is a synthetic collagen peptide derived from the structures of human collagen types IV and XVII (two key basement membrane collagen proteins).As a signal peptide, it binds to fibroblasts to trigger the synthesis of intercellular matrix molecules, providing the skin with regenerative signals analogous to those required for intercellular matrix remodeling. It acts simultaneously across three anatomical layers: the epidermis, dermis, and dermo-epidermal junction (DEJ).

Powerful collagen and hyaluronic acid stimulants: Clinical studies by manufacturers demonstrate that hexapeptide-9 can increase overall collagen production by up to 117%, with type IV collagen levels rising by as much as 357% and hyaluronic acid production increasing by 267%.It also enhances the synthesis of laminin-5 and integrins, thereby enriching the extracellular matrix network in the dermal layer.

Significantly anti-wrinkle and acne scar repair: By inhibiting the activity of metal matrix metalloproteinase MMP-1, it blocks the collagen degradation pathway.Clinical data demonstrate that hexapeptide-9 reduces the surface area of deep wrinkles by an average of 68%, while moderate wrinkles are reduced by an average of 51%.Furthermore, it demonstrates highly significant efficacy in the repair of acne scars.

Barrier repair and epidermal regeneration: Upregulation of filaggrin expression, restoration of the stratum corneum lipid structure, and enhancement of skin barrier function.The display barrier repair efficiency improved by 42% in vitro experiments.It simultaneously promotes the proliferation and differentiation of epidermal keratinocytes, thereby repairing damage to mature epidermal components (keratin and filaggrin).

III. Recommended Addition Ratios and Application Scenarios

Hexapeptide-9 exhibits excellent water solubility and can be directly added to the aqueous phase of cosmetic formulations at temperatures below 40°C, during the final stage of formulation.It can be applied to various formulations including serums, emulsions, creams, masks, and eye creams.

Daily anti-aging serum/creme: Recommended concentration is 0.01%–0.1% (based on pure powder).As a key anti-aging ingredient in daily skincare routines, its morning and evening application effectively reduces fine wrinkles and enhances skin elasticity.

Intensive repair/anti-wrinkle products: Recommended concentration is 0.1%–0.3% (as pure powder).For the repair of deep wrinkles and acne scars, it provides targeted restorative effects.Third-party clinical trials have demonstrated that 28 days of use can increase collagen density by 37%.

Eye care (eye cream/mask): The recommended application concentration is 0.05%–0.1%.For crow's feet and fine periorbital wrinkles, continuous use for 2–4 weeks results in a reduction rate of approximately 30% in dynamic wrinkles.

Solution formulation addition: For solution-form raw materials, the recommended addition amount is 1%–3% (based on the total weight of the finished product).

IV. Formulation Recommendations and Safety Compliance

Synergistic Gold Combination: It can form a multi-target anti-aging peptide matrix with signal peptides such as palmitoyl tripeptide-5 and palmitoyl tetrapeptide-7; synergize with hyaluronic acid to enhance moisturizing and volumizing effects; and work in concert with antioxidants like vitamin A (retinol) to improve overall wrinkle-reducing and skin-tightening efficacy.

Safety and Compliance: Hexapeptide-9 is non-irritating to the skin and does not cause allergic reactions, making it suitable for all skin types, including sensitive skin.Its structure is derived from the natural collagen sequence of the human body, exhibiting excellent biocompatibility.

Application range: Suitable for anti-wrinkle and anti-aging products, acne scar repair products, eye care products, as well as men's skincare and foundation products.