I. Basic Product Information
Chinese name: Acetyl tetrapeptide-9 (also known as Dermican)
English name: Acetyl Tetrapeptide-9
CAS Number: 928006-50-2
Molecular formula: C22H33N7O9
Molecular weight: 539.54 g/mol
Amino acid sequence: Ac-Gln-Asp-Val-His (acetylglutamine-aspartic acid-valine-histidine)
Specification: White powder (purity ≥98%) or transparent liquid
Solubility: Excellent water solubility with strong formulation compatibility.
Storage conditions: The powder should be stored sealed and protected from light at 2°C to 8°C; for long-term storage, freezing at-20°C is recommended; the liquid should be stored sealed and protected from light at room temperature.
Package:100g per bag
MOQ 500G
II. Core Efficacy and Mechanism of Action
Acetyl tetrapeptide-9 is a synthetic matrix metalloproteinase peptide specifically designed to optimize collagen fiber function.It not only mimics the functional effects of hyaluronic acid in regulating fibroblast activity, but also stands as the sole peptide component currently capable of enhancing collagen structure cohesion.Its core efficacy is primarily manifested in the following three dimensions:
Reconstruction of dermal support structures: This component is specifically designed to enhance the binding of "lumican" between collagen fibers.By stimulating the synthesis of type I collagen and basement membrane glycosaminoglycans, it effectively enhances the supportive tissues of the skin, increases its density and thickness, strengthens the skin's resistance to stretching, thereby achieving deep firming effects.
Outstanding ocular anti-aging and edema reduction effects: As a leading agent in the field of under-eye bag and dark circle treatment, Acetyl Tetrapeptide-9 is an effective angiotensin-converting enzyme (ACE) inhibitor that improves periorbital microcirculation and reduces dark circles.Meanwhile, its potent anti-edema and drainage properties can effectively reduce the volume of under-eye bags within a relatively short period (approximately 15 days), achieving optimal results in bag reduction.
Comprehensive wrinkle reduction and barrier repair: By promoting dermal remodeling, it significantly diminishes wrinkles and fine lines while restoring skin elasticity and suppleness.Furthermore, this ingredient exhibits antioxidant and anti-inflammatory properties, which help soothe the skin, alleviate redness, swelling, and sensitivity, while enhancing skin hydration to impart a noticeably smooth texture.
III. Recommended Addition Ratios and Application Scenarios
The acetyl tetrapeptide-9 formulation exhibits excellent compatibility and stable properties, allowing easy incorporation into various dosage forms including emulsions, serums, creams, and gels.It is recommended to add it during the post-formulation stage under low-temperature conditions below 40°C.
Daily anti-aging serum/crème: The recommended concentration range is 100 ppm to 500 ppm (equivalent to 0.01%–0.05% based on pure powder).As a key firming ingredient in daily skincare regimens, using it morning and evening helps reduce skin sagging and enhance overall firmness.
Eye care (eye cream/eye serum): The recommended application concentration is 0.02%–0.05%.For under-eye puffiness, dark circles, and fine wrinkles around the eyes, it delivers potent drainage, firming, and wrinkle-reducing effects.
High-end intensive repair/anti-wrinkle products: Recommended concentration is 0.05%–0.1%.As a high-concentration active ingredient, it effectively addresses deep wrinkles and enhances the quality of skin support tissues.
IV. Formulation Recommendations and Safety Compliance
Optimal Gold Combination: It can be perfectly formulated with Bosetin (hydroxypropyl tetrahydropyranol tris), which stimulates the synthesis of glycosaminoglycans internally, while Acetyl Tetrapeptide-9 strengthens external collagen fibers, forming a three-dimensional anti-aging closed-loop system characterized by "internal reconstruction + external support." Additionally, it synergizes with hyaluronic acid and various antioxidant plant extracts to maximize firming and wrinkle-reducing effects.
Safety and Compliance: This ingredient has a risk level of Grade 1 (the safest grade), is non-irritating to the skin, safe for pregnant women, and exhibits extremely mild properties.Suitable for various anti-wrinkle, firming, under-eye bag reduction, and anti-aging care products for sensitive skin.
