I. Basic Product Information

Chinese name: Acetyl tetrapeptide-11 (alias: Syniorage)

English name: Acetyl Tetrapeptide-11

CAS Number: 928006-88-6

Molecular formula: C27H38N4O7

Molecular weight: 530.61 g/mol

Amino acid sequence: Ac-Pro-Pro-Tyr-Leu (acetylproline-proline-proline-tyrosine-leucine)

Specification: White powder (purity ≥98%) or transparent liquid

Solubility: Well soluble in water; insoluble in oil.

Storage conditions: The powder shall be stored sealed and protected from light at 2°C to 8°C; for long-term storage, it is recommended to freeze at-20°C.

Package:100g per bag

MOQ 500G

II. Core Efficacy and Mechanism of Action

Acetyl tetrapeptide-11 is a next-generation, mild yet highly effective benchmark anti-aging ingredient. Acting as a genuine cellular messenger, it delivers regenerative signals to skin cells.Its core mechanism involves targeted regulation of the extracellular matrix (ECM) in skin cells, simultaneously activating the production of various youthful proteins to achieve firming and regeneration at the cellular level.

Strengthening the basement membrane and epidermal cohesion: This component significantly stimulates the synthesis of type XVII collagen (a basement membrane anchoring protein) and sulfatated acetylheparan synthase-1 (the polyligand proteoglycan syndecan-1).This effectively restores the weakened dermo-epidermal junction (DEJ), enhances the cohesion of epidermal keratinocytes, thereby improving skin micro-loosening and fragility caused by aging.

Mild wrinkle-reducing effects comparable to retinol: A clinical double-blind controlled trial demonstrated that after 8 weeks of use of a product containing 0.2% acetyl tetrapeptide-11, the depth of periorbital wrinkles decreased significantly by 28%, and skin elasticity improved by 19%.Its wrinkle-reducing efficacy rivals that of traditional retinol, yet it completely eliminates its irritancy while demonstrating excellent tolerability.

Multidimensional Anti-Aging and Photoprotection: In addition to promoting collagen synthesis, it stimulates the production of proteoglycan-1 (Perlecan), increasing skin hydration by 32%; simultaneously activates photolyase, reducing UV-induced photoaging damage by 53%.Furthermore, it promotes the proliferation of epidermal keratinocytes, increases cell density, and achieves intensive tissue regeneration.

III. Recommended Addition Ratios and Application Scenarios

The acetyl tetrapeptide-11 formulation exhibits excellent compatibility and is perfectly suitable for various dosage forms including serums, eye creams, face creams, emulsions, lyophilized powders, and hair care products.It is recommended to add it during the post-formulation stage under low-temperature conditions below 40°C.

Daily anti-aging serum/creme: The recommended dosage is 0.05%–0.2% (based on pure powder).As a key anti-aging ingredient in daily skincare routines, using it morning and evening effectively enhances skin elasticity and firmness.

Eye care (eye cream/eye serum): The recommended application concentration is 0.1%–0.2%.For fine wrinkles and sagging around the eyes, it delivers potent wrinkle-reducing and lifting effects.

High-end intensive repair/anti-wrinkle products: Recommended concentration is 0.2%–0.5%.As a high-concentration active ingredient, it effectively addresses deep wrinkles, skin laxity, and photoaging damage.

IV. Formulation Recommendations and Safety Compliance

Optimal synergistic combination: When formulated with bosetin, it exhibits synergistic effects on various collagen types to establish a multi-layered anti-aging network; when combined with nicotinamide, it reduces wrinkles while enhancing skin barrier function and achieving even skin tone; when paired with hyaluronic acid cross-linked polymers, it forms a 3D water-retaining network.

Safety and Compliance: This ingredient has a risk level of Grade 3, exhibits mild properties, demonstrates excellent skin tolerance, is non-acneogenic, and generally poses no adverse effects on pregnant women.Suitable for all skin types, especially ideal as an anti-aging care product for mature and sensitive skin.