I. Basic Product Information

Chinese name: Tripeptide-10-citrulline (also known as core proteoglycan peptide, decorinyl)

English name: Tripeptide-10 Citrulline

CAS Number: 960531-53-7

Molecular formula: C22H42N8O7

Molecular weight: 530.62 g/mol

Amino acid sequence: Lys-Asp-Ile-Citrulline (lysine-aspartic acid-isoleucine-citrulline)

Physical properties: White to off-white powder (purity ≥98%)

Storage conditions: The powder shall be stored in a sealed container protected from light at 2°C to 8°C in a refrigerator. For long-term storage, it is recommended to freeze at-20°C.

Package: 100g per bag

MOQ 500G

II. Core Efficacy and Mechanism of Action

Tripeptide-10-citrulline is a next-generation cosmetic peptide that mimics the sequence and activity of human natural decorin (core proteoglycan).Unlike the commonly available "collagen-promoting" signal peptides on the market, this product focuses specifically on "quality control of collagen fibers and tissue organization," with its core efficacy manifesting primarily in three key aspects:

The "tissue manager" of collagen fibers: With advancing age, the core protein glycan in the skin gradually loses its functionality, leading to disordered arrangement and bundling of collagen fibers.Tripeptide-10-calcitonate accurately mimics the function of core proteoglycan, binds to collagen fibrils, and regulates the formation process of collagen fibers, ensuring uniform diameter and regular spacing of collagen fibers, thereby enhancing their cohesion and stability.

Rebuilding skin microstructure and firmness: By optimizing the spatial structure of collagen, this ingredient significantly improves skin microstructure while enhancing skin softness and elasticity.Clinical trials demonstrated that after 28 days of using the formulation containing tripeptide-10-citrulline, skin flexibility and appearance improved by 54%, effectively combating skin laxity and sagging caused by morphological alterations in collagen tissue.

Excellence in Moisturization and Barrier Stability: This ingredient maintains high skin hydration levels and reduces transepidermal water loss (TEWL).In the sensitive skin repair test, the formulation containing 0.03% tripeptide-10-citrulline combined with ingredients such as ceramides reduced epidermal water loss by 32%, imparting the skin with a soft and moisturized texture.

III. Recommended Addition Ratios and Application Scenarios

Tripeptide-10-citrulline is an active ingredient characterized by "high efficacy at low dosage" and exhibits strong formulation compatibility; however, potential incompatibilities should be noted.It is recommended to add the aqueous phase under low-temperature conditions below 45°C during the post-formulation stage.

Daily anti-aging serum/cream: Recommended concentration is 0.01%–0.05% (based on pure powder).At this concentration, it effectively activates fibroblasts and enhances collagen synthesis and proliferation rates by over 19%. As a core ingredient in daily skincare regimens, it gently improves skin texture.

High-end intensive repair/anti-wrinkle products: Recommended concentration is 0.05%–0.1% (based on pure powder).At a concentration of 0.05%, collagen production reaches its peak, effectively addressing deep wrinkles and issues related to collagen fiber arrangement.

Sensitive skin/barrier repair products: Recommended concentration is 0.03%–0.05%.Combinating ingredients such as ceramide and myricetin to deliver deep hydration and enhanced barrier protection.

IV. Formulation Recommendations and Safety Compliance

Optimal Gold Combination: When formulated with acetylated tetrapeptide-5, it achieves a dual anti-aging effect of "promoting collagen synthesis and inhibiting MMP-1-mediated collagen degradation" through a closed-loop mechanism; when combined with hyaluronic acid or vitamin C derivatives, it further enhances moisturizing efficacy, volume enhancement, and antioxidant effects.

Incompatibility and process control: This component is sensitive to cationic surfactants (e.g., quaternary ammonium salts-18) and copper ions; high concentrations of cationic surfactants can induce peptide chain aggregation and precipitation, while trace amounts of copper ions may catalyze oxidative cleavage.The recommended formulation should have a pH value controlled between 5.5 and 6.5, and the use of formaldehyde-releasing preservatives should be avoided.

Safety and Compliance: This ingredient is mild in nature and suitable for various anti-wrinkle, firming, moisturizing, and age-reversal skincare products for sensitive skin.

V. Application Fields and Brand Applications

Tripeptide-10-calcitonate is widely used in high-end anti-aging skincare products, including facial serums, creams, eye creams, neck creams, and body lotions.In terms of brand application, this ingredient is frequently used as the core active component in peptide-based formulations marketed for their "deep wrinkle-reduction and skin repair" benefits.For example, in renowned patented formulations such as the "8-Peptide Anti-Aging Serum," tripeptide-10-citrulline serves as the primary active ingredient, working synergistically with Pseudomonas alternata extract and hydrolyzed proteins to comprehensively promote the synthesis and stability of type I, III, and IV collagen. Clinical trials over 30 days demonstrated a 28.94% reduction in skin wrinkle depth.