I. Basic Product Information

Chinese name: Myristoyl tripeptide-31 (also known as retinoic acid peptide or retinoid-like peptide)

English name: Myristoyl Tripeptide-31

Composition: A synthetic peptide synthesized by the reaction of fatty acid myristic acid with tripeptide-31, which is a long-chain peptide fatty acid exhibiting retinoid-like properties.

Commercial active ingredient: DermaPep™ A350 (a solution-form active ingredient composed of butanediol and myristoyl tripeptide-31)

Specification: White powder (purity ≥95%) or transparent liquid (in solution form)

Solubility: The powder is slightly soluble in water, and the solution can be directly added to aqueous formulations.

Storage conditions: The powder shall be stored in a sealed container protected from light at 2°C to 8°C in a refrigerator. For long-term storage, it is recommended to freeze at-15°C to-20°C.

II. Core Efficacy and Mechanism of Action

Myristoyl tripeptide-31, hailed as the "retinoic acid peptide," is a biomimetic tripeptide with retinol-like efficacy.It achieves equivalent anti-aging effects to retinol while completely avoiding its side effects such as dryness, peeling, and photosensitivity, making it an ideal alternative for sensitive skin in the field of anti-aging treatments.Its core efficacy encompasses four key dimensions:

Powerful anti-aging and wrinkle-reducing effects: By inhibiting the gene transcription and translation of matrix metalloproteinase MMP-1, it blocks the degradation pathway of collagen; simultaneously promoting the production of type I procollagen, exerting a dual action of "promoting synthesis + suppressing degradation" to significantly combat light-induced aging.Clinical trials demonstrated that 30 female volunteers aged 35–60 years who used the product containing a 4% tripeptide solution twice daily exhibited a 30% reduction in the number of periorbital wrinkles, a 35% decrease in wrinkle area, and a 33% reduction in wrinkle length after two months of treatment.

Skin brightening and spot reduction: It inhibits the expression of melanin genes, melanin synthesis, and tyrosinase activity, effectively reducing age spots and irregular pigmentation, improving skin unevenness, and enhancing skin brightness and translucency.

Constricts pores: By improving the structure of collagen fibers and regulating sebum secretion, it directly reduces pore size.Clinical data demonstrate that pore size decreases by 11.3% after two months of use.

Anti-inflammatory repair: Inhibits the production of pro-inflammatory cytokines and alleviates skin inflammatory responses, making it suitable for daily repair of acne-prone and sensitive skin.

III. Recommended Addition Ratios and Application Scenarios

The myristoyl tripeptide-31 formulation exhibits excellent compatibility and can be applied in various dosage forms including serums, creams, lotions, masks, eye creams, and acne treatment and repair products.The solution-forming ingredient (DermaPep A350) should be added during the final formulation stage at temperatures below 40°C.

Daily anti-aging serum/crème: The recommended concentration for solution formulations is 1%–4% (based on DermaPep A350 solution).As a key anti-aging ingredient in daily skincare routines, its morning and evening application effectively reduces fine wrinkles and brightens skin tone.

Eye care (eye cream/eye serum): The recommended concentration for solution formulations is 2%–4%.For crow's feet and fine wrinkles around the eyes, it delivers a gentle yet effective wrinkle-reducing effect.

Pore management/oil-control products: The recommended concentration for solution formulations is 2%–5%.For skin with enlarged pores and excessive sebum secretion, it delivers dual benefits of pore tightening and oil control.

Acne repair products: The recommended concentration for solution formulations is 3%–5%.Leveraging its anti-inflammatory properties, it alleviates redness, swelling, and inflammation in acne-prone skin while improving post-acne hyperpigmentation.

IV. Formulation Recommendations and Safety Compliance

Optimal combination with gold: Can be formulated with hyaluronic acid to enhance moisturizing and volumizing effects, synergistically reducing fine wrinkles; when combined with vitamin C derivatives (e.g., magnesium ascorbate phosphate), it provides anti-wrinkle benefits while brightening skin tone and fading pigmentation; when paired with nicotinamide, it achieves a multi-effect synergy of wrinkle reduction, oil control, and pore minimization.

Pharmacological advantages: Compared to retinol (A-retinol), myristoyl tripeptide-31 exhibits no phototoxicity, requires no tolerance induction, can be applied morning and evening without light protection, and is particularly suitable for pregnant women and individuals with sensitive skin.

Safety and Compliance: This ingredient is safe and non-toxic, with no irritating side effects, and suitable for all skin types, including sensitive skin, acne-prone skin, and mature skin.

V. Application Fields and Brand Usage Demonstration

Myristoyl tripeptide-31 is widely used in high-end anti-aging skincare products, with applications spanning the following areas:

Anti-wrinkle and anti-aging products: As the core active ingredient, they are incorporated into facial serums, creams, eye creams, etc., emphasizing the concept of "retinoid-like gentle anti-aging effects".

Skin-lightening and spot-reducing products: Utilizing their ability to inhibit melanin synthesis, they are incorporated into whitening serums, spot-reducing creams, and similar formulations.

Pore management products: As the core ingredient for pore contraction, they are used in pore-refining serums and oil-control lotions.

Acne repair products: Utilizing their anti-inflammatory properties, they are applied in acne-generating gels and post-acne scar repair serums.

Men's skincare products: Due to their gentle and non-irritating properties, they are suitable for anti-aging and pore management formulations designed for men.

In brand applications, myristoyl tripeptide-31 (DermaPep A350) serves as the core ingredient of the "retinoic acid peptide" concept, featured in skincare products marketed for their "non-irritating anti-aging" and "pore-minimizing" properties. It works synergistically with classic ingredients such as hyaluronic acid and vitamin C to create multi-action anti-aging formulations.