Hexapeptide-3

1、 Product basic file

Chinese name: Hexapeptide-3 (also known as fibronectin peptide)

English name: Hexapeptide-3

CAS number: 1205679-02-2

Amino acid sequence: H-Glu-Glu-Met-Gln-Arg-Arg-NH ₂ (EEMQRR)

Molecular formula: C ∝₂ H ₅₈ N ₁₄ O ₁₁ S

Molecular weight: 846.96 g/mol

Appearance specification: White solid powder (purity ≥ 98%)

Solubility: soluble in DMSO; Water solubility is average, it is recommended to use ultrasound assisted dissolution

Storage conditions: Powder state sealed and away from light, can be stored for 3 years at -20 ℃, and 2 years at 4 ℃; After preparing the solution, it needs to be divided and stored at -80 ℃ for 6 months and -20 ℃ for 1 month to avoid repeated freezing and thawing

2、 Core efficacy and mechanism of action

Hexapeptide-3 is a biomimetic small molecule peptide that mimics the 6-amino acid fragment sequence of human fibronectin type III unit. Its core efficacy and mechanism of action are mainly reflected in the following dimensions:

Promoting ECM protein expression and cell adhesion (core efficacy): Hexapeptide-3 can promote the expression of laminin-5 and β 1 integrin, enhance the adhesion between cells and the extracellular matrix (ECM), and promote tissue remodeling and skin repair.

Promoting collagen synthesis and tissue repair: By simulating the physiological function of fibronectin, hexapeptide-3 can promote collagen adhesion and generation, improve the structural integrity of extracellular matrix, and enhance the skin's self repair ability.

Enhance skin self-healing ability: Hexapeptide-3 has a small molecular weight and can effectively penetrate into the basal layer of the skin, regenerate and repair the skin, comprehensively improve the skin's condition, and enhance the skin's self-healing ability.

Lip plumpness and lip care: Hexapeptide-3 performs outstandingly in lip care, making lips fuller, more moisturized, and smoother, and is widely used in high-end lip care products.

Enhance integrin gene expression: Hexapeptide-3 can enhance the expression of genes responsible for integrin synthesis, increase skin repair signals, and accelerate the healing process of damaged skin.

3、 Recommended addition ratio and application scenarios

Hexapeptide-3 formula has good compatibility and can be widely used in various personal care formulas.

Anti aging repair essence/face cream: as a core active ingredient, it can promote ECM protein expression and cell adhesion, repair damaged skin, improve skin density and elasticity, and improve signs of aging.

Lip care products (special application): Hexapeptide-3 is widely used in the field of lip care, and can be used in lip essence, lip mask, lipstick and other products to make lips more plump, moist and smooth.

Organizational repair and regeneration products: using their function to simulate fibronectin, applied to the repair and remodeling of damaged skin, such as postoperative repair, sensitive skin repair, and other products.

Moisturizing lotion/facial mask: combined with its ability to enhance skin barrier function, it can be used in daily moisturizing products to improve skin moisture content and smoothness.

4、 Formula recommendations and safety compliance

Gold synergy combination:

Compound with Copper Tripeptide-1: Both act on the remodeling and repair of ECM, synergistically enhancing the overall repair and regeneration ability of the skin.

Compound with hyaluronic acid: Hexapeptide-3 promotes ECM protein production, hyaluronic acid provides instant moisturizing and filling, both internally and externally, enhancing skin hydration and plumpness.

Compound with vitamin C derivatives: Vitamin C promotes collagen synthesis, while hexapeptide-3 promotes ECM adhesion and tissue repair, achieving a comprehensive anti-aging effect.

Compatibility and process suggestions: Hexapeptide-3 belongs to the signal active peptide category, and it is recommended to add it in the later stage of the formula under low temperature conditions to maximize its biological activity. After preparing the solution, it should be packaged and stored separately to avoid repeated freezing and thawing.

Safety compliance: Hexapeptide-3 has high safety and minimal side effects. It has been included in China's "Catalogue of Used Cosmetic Ingredients" (IECIC) and meets domestic cosmetic regulatory requirements.

5 ⚠️  Important distinction: Hexapeptide-3 ≠ Acetyl Hexapeptide-3 (Argireline)

6、 Application Fields and Market Supply

Hexapeptide-3, as a biomimetic peptide of fibronectin, is widely used in the repair and lip care cosmetics market.