Palmitoyl Tetrapeptide-10
1、 Product basic file
Chinese name: Palmitoyl Tetrapeptide-10 (also known as Black Hair Peptide)
English name: Palmitoyl Tetrapeptide-10
CAS number: 887140-79-6
Molecular formula: C ₄₁ H ₇₂ N ₆ O ₇
Molecular weight: 761.05 g/mol
Amino acid sequence: {Palmitoyl-Lys}-Thr-Phe-Lys (PTFK for short)
Amino acid composition: composed of four types of amino acids: lysine (Lys), threonine (Thr), phenylalanine (Phe), and lysine (Lys). The N-terminus is modified with palmitoylation to enhance skin permeability
Appearance specifications: White to off white solid powder, purity usually ≥ 98% (HPLC)
Solubility: Slightly soluble in water
Storage conditions: sealed and away from light, stored in powder form at -80 ℃ for 2 years, stored at -20 ℃ for 1 year; After preparing the solution, store it at -80 ℃ for 6 months and -20 ℃ for 1 month to avoid repeated freezing and thawing
2、 Core efficacy and mechanism of action
Palmitoyl tetrapeptide-10 is a tetrapeptide modified with palmitoyl, which significantly enhances its lipid solubility and skin penetration ability. Its efficacy covers two major fields: skin care and hair care. The core efficacy and mechanism of action are mainly reflected in the following dimensions:
Activation of cellular energy and promotion of collagen regeneration (core efficacy): Palmitoyl tetrapeptide-10 can activate the cellular energy "master switch" PGC1- α, increasing its expression by 1.7 times, thereby promoting mitochondrial regeneration by 1.23 times and cellular energy ATP by 1.17 times. Experimental data show that it can increase the expression of type I collagen 2.26 times and type III collagen 4.29 times, and its ability to promote collagen regeneration is significantly better than the star anti-aging polypeptide acetylhexapeptide-8 (Argireline) commonly seen in the market.
Improving skin barrier function: Palmitoyl tetrapeptide-10 works synergistically with other active ingredients to increase the expression of keratinocyte adhesion marker corneodesmosin and keratinocyte terminal differentiation marker filaggrin, thereby reducing skin permeability and strengthening skin barrier function. It is suitable for repairing sensitive skin syndrome.
Anti inflammatory and Soothing: By inhibiting the production of excessive interleukins, regulating the inflammatory signaling pathway of the skin, reducing skin redness, sensitivity, and irritation reactions, creating a healthier microenvironment for the skin.
Anti glycation and antioxidant: Resist the damage of glycation reactions to collagen and elastin fibers (glycation can make collagen fibers harder and lose elasticity), and maintain the elasticity and toughness of the skin. Simultaneously combating cumulative damage caused by external pressures such as ultraviolet radiation and environmental pollution, and assisting in skin repair.
Brightening skin tone and improving skin quality: By accelerating the process of skin keratin metabolism and renewal, it promotes the improvement of skin brightness and smoothness, keeping the skin in a crystal like transparent and smooth state.
Black Hair/Anti White Hair Effect (in the field of hair care): Palmitoyl Tetrapeptide-10 can act on the two main causes of white hair - melanin reduction and oxidative stress response, stimulating the production of natural pigments in hair, gradually restoring natural hair color, while resisting hair aging and preventing white hair from appearing.
3、 Recommended addition ratio and application scenarios
Palmitoyl tetrapeptide -10 formula has good compatibility and can be added to essence liquid, face cream, lotion, eye cream, facial mask and other formulations.
Recommended addition ratio:
Recommended concentration of commodity solution: 3% (based on commodity solution)
Pure peptide active concentration: 0.0006% (when used alone)
Anti aging and firming essence/face cream: as the core active ingredient, it uses its ability to activate PGC1- α and promote collagen regeneration, focusing on the concept of "cell energy charging", and comprehensively improves multiple signs of aging such as skin relaxation, wrinkles and dullness.
Sensitive skin barrier repair products: utilizing their ability to enhance the expression of keratin bridging protein and silk fibroin, strengthen the skin barrier, and provide repair and care for sensitive skin syndrome.
Eye care products: used for eye cream, eye essence, etc., to use its ability to improve firmness, fine lines, and signs of eye relaxation and aging.
Brightening and skin rejuvenation products: Utilize their ability to accelerate keratin metabolism, enhance skin brightness and smoothness, and create a "crystal skin" concept product.
Black hair/anti white hair care products: apply to scalp essence, hair care fluid, etc., use its ability to stimulate melanin production and prevent white hair, and focus on the concept of "restoring natural hair color from the root".
4、 Formula recommendations and safety compliance
Gold synergy combination:
Compound with hyaluronic acid: Palmitoyl tetrapeptide-10 is responsible for deep repair and collagen regeneration, while hyaluronic acid provides instant moisturizing and filling, both internally and externally.
Compound with antioxidant components such as vitamin C: The anti glycation ability of palmitoyl tetrapeptide-10 synergizes with the antioxidant ability of vitamin C, providing comprehensive resistance to photoaging and environmental damage.
Compound with other active peptides: Can be combined with acetyl hexapeptide-8 (botulinum toxin like peptide), palmitoyl tripeptide-1 (Matrixyl) ®） By combining ingredients, a comprehensive anti-aging system is constructed that promotes collagen production, inhibits muscle contraction, and repairs the barrier.
Compound with ergothionein: The seventh generation ultra anti purple bottle of Nature Hall adopts a compound scheme of palmitoyl tetrapeptide-10 and 99.9% L-type ergothionein, achieving multiple effects of anti wrinkle, brightening, and repairing.
Compatibility and process suggestion: Palmitoyl tetrapeptide-10 is slightly soluble in water. It is recommended to add it at a low temperature during the later stage of the formula to preserve its biological activity to the greatest extent possible. Palmitoylation modification endows it with good skin penetration ability, which can be increased by 8.5 times after structural modification. It can penetrate the stratum corneum within half an hour after application, reach the active epidermal layer within two hours, and reach the dermis layer within eight hours.
Safety compliance: Palmitoyl tetrapeptide-10 is a pure synthetic tetrapeptide, not of animal origin, with high safety. The Independent Cosmetic Ingredient Review (CIR) classifies it as a skin conditioner.
5、 Application Fields and Market Supply
Palmitoyl tetrapeptide-10, as a multifunctional active peptide with dual effects of skincare and hair care, has broad application prospects in the skincare and hair care markets.
Research and development background: Palmitoyl tetrapeptide-10 was initially included in the cosmetic ingredient database as a skin conditioner. In recent years, the Natural Hall Group, in collaboration with the Aging Science Innovation Research Center of Tsinghua Yangtze River Delta Research Institute, has utilized an AI computational biology platform to screen candidate peptides related to PGC1- α activation from over 2.8 million yeast proteins. After structural modification, the resulting peptide, palmitoyl tetrapeptide-10, has been named "Ximoyin" ® It was officially launched in 2026 in the seventh generation ultra anti small purple bottle essence of Natura Hall.
Domestic brand application: The seventh generation anti purple bottle of Natural Tang is a benchmark application case of palmitoyl tetrapeptide-10 in the domestic market, focusing on the concept of "cell energy charging+collagen regeneration", and jointly tested with SGS for 21 days to verify its effectiveness.
Market prospects: Palmitoyl tetrapeptide-10, as a multifunctional active peptide that covers both skincare (anti-aging, barrier repair, brightening) and hair care (black hair, anti white hair) fields, has broad market application space. With the endorsement and promotion of top brands such as Natural Hall, the awareness and application proportion of this ingredient in the domestic market are expected to rapidly increase.
