Palmitoyl tripeptid-8
1、 Product basic file
Chinese name: Palmitoyl tripeptid-8
English name: Palmitoyl Tripeptide-8
CAS number: 936544-53-5
Molecular formula: C ∝₇ H ₆₁ N ₉ O ₄
Molecular weight: 695.94 g/mol
Amino acid sequence: {Palmitoyl-His}-{D-Phe}-Arg-NH ₂ (Palmitoyl-Histoyl-D-Phenylalanyl-Arginimide)
Amino acid composition: composed of histidine (His), D-phenylalanine (D-Phe), and arginine (Arg), with palmitoylation modification at the N-terminus to enhance skin permeability and amidation modification at the C-terminus to enhance stability
Appearance specifications: White to off white solid powder, purity usually ≥ 98.0% (HPLC)
Solubility: Easily soluble in water
Density: 1.20 ± 0.1 g/cm ³ (calculated value)
Storage conditions: Sealed and protected from light, frozen storage (-20 ℃), shelf life of 24 months
2、 Core efficacy and mechanism of action
Palmitoyl tripeptide-8 is a synthetic biomimetic peptide inspired by alpha melanocyte stimulating hormone (α - MSH), which originates from pre alpha melanocortin (POMC) and is a natural anti-inflammatory regulator in the human body. Palmitoyl tripeptid-8 retains high affinity between alpha MSH and melanocortin receptor type 1 (MC1-R), but has almost no melanin activity, thus focusing on exerting anti-inflammatory and soothing effects. Its core efficacy and mechanism of action are mainly reflected in the following dimensions:
Specific anti-inflammatory and anti-inflammatory cytokine release inhibition (core efficacy): Palmitoyl tripeptid-8 effectively inhibits the release of UVB induced pro-inflammatory cytokine IL-8 by binding to and activating MC1-R receptors on the surface of keratinocytes. In vitro experiments have shown that the inhibition rate of IL-8 in keratinocytes irradiated with UVB can reach 32%, which is comparable to that of α - MSH; In fibroblasts stimulated by IL-1, the inhibition rate of IL-8 was as high as 64%, significantly better than that of α - MSH. Meanwhile, palmitoyl tripeptid-8 can also interfere with the production of TNF - α, prevent increased vascular permeability, and reduce symptoms of neurodermatitis such as edema and redness.
Soothing and calming, reducing skin sensitivity: Palmitoyl tripeptid-8 can maintain and restore normal skin sensitivity thresholds. In a skin explant model exposed to Substance P, a pro-inflammatory neuropeptide, palmitoyl tripeptid-8 significantly reduced the number of dilated capillaries by 30%, dilated vessel area by 51%, and edema by 60%.
Clinical validated immediate soothing effect: A clinical study evaluated the soothing effect of palmitoyl tripeptid-8 on 13 volunteers. First, induce local skin inflammation and redness with 0.5% sodium dodecyl sulfate (SDS). After 24 hours, apply a formula or placebo containing 4 × 10 ⁻⁶ M palmitoyl tripeptid-8 three times a day for two days. Thermal imaging measurements showed that the increase in skin temperature caused by SDS was reduced by an average of 78% in the palmitoyl tripeptid-8 treated area, while there was no significant improvement in the placebo group. Video microscopy observation also confirmed significant relief of redness, swelling, and inflammation.
Anti aging auxiliary effect: Clinical trials have shown that skincare products containing palmitoyl tripeptid-8 can significantly reduce skin sagging, improve and fade age lines, and its activity is significantly higher than that of 10 ppm palmitoyl pentapeptide-4 (Matrixyl) ®）。
Antioxidant and barrier repair: Palmitoyl tripeptid-8 also has certain antioxidant properties, helping to protect the skin from free radical damage, while creating a favorable environment for skin barrier repair by inhibiting inflammatory reactions.
3、 Recommended addition ratio and application scenarios
Palmitoyl tripeptide-8 formula has good compatibility and can be added to essence liquid, face cream, lotion, eye cream, facial mask and other formulations.
Recommended addition ratio:
Recommended dosage: 0.3% to 2.5% (based on the product solution)
Pure peptide active concentration: approximately 4 × 10 ⁻⁶ M (clinically effective concentration)
Sensitive Skin Soothing and Repairing Products: As a core anti-inflammatory and soothing ingredient, it quickly relieves discomfort symptoms such as redness, burning, stinging, and itching in seasonal sensitivity, post beauty repair, contact dermatitis, eczema, and other scenarios.
Anti inflammatory and anti allergic skin care products: used in lotion, day creams, night creams and other products, use its ability to inhibit the release of IL-8 and TNF - α, and block the inflammatory cascade reaction from the source.
Eye care products: apply to eye essence, etc., use its ability to reduce telangiectasia and edema, and improve periocular redness and edema.
Peptide synergistic anti sensitization scheme: Combined with acetyltetrapeptide-15 (reducing neurogenic response and increasing tolerance threshold), it works synergistically from the two targets of "reducing neural excitability+inhibiting inflammatory factors" to achieve a more comprehensive anti sensitization effect.
4、 Formula recommendations and safety compliance
Gold synergy combination:
Combined with Acetyl Tetrapeptide-15 (Best Partner): Acetyl Tetrapeptide-15 acts on opioid μ receptors, reducing neuronal excitability and increasing skin tolerance threshold; Palmitoyl tripeptid-8 acts on MC1-R receptors and inhibits the release of inflammatory factors. The two synergistically exert anti allergic effects from different targets, and clinical data shows that the combined effect is better than that of a single peptide.
Compound with Acetyldipeptide-1 Cetearyl Ester: Acetyldipeptide-1 Cetearyl Ester exerts immediate analgesic and soothing effects by stimulating the release of endorphins, while Palmitoyl Tripeptid-8 exerts sustained anti-inflammatory effects by inhibiting inflammatory factors. The two complement each other, achieving a dual effect of "immediate relief+sustained anti-inflammatory".
Combined with Acetyl Tetrapeptide-33 and Acetyl Tetrapeptide-40: Construct a comprehensive anti sensitivity system with multiple targets and pathways, covering various types of inflammation such as neurogenic inflammation, vascular reactive inflammation, and immunogenic inflammation.
Compound with ceramide: Palmitoyl tripeptid-8 is responsible for immediate anti-inflammatory and soothing effects, while ceramide is responsible for long-term barrier repair, both internally and externally.
Compatibility and process suggestions: Palmitoyl tripeptid-8 is easily soluble in water and compatible with most water-based formulations. It is recommended to add it at the post formulation stage and under low temperature conditions to preserve its biological activity to the greatest extent possible. Palmitoylation modification endows it with excellent skin penetration ability.
Safety compliance: Palmitoyl tripeptide-8 has been included in China's "Catalogue of Used Cosmetic Raw Materials" (IECIC 2015 edition), which meets domestic cosmetic regulatory requirements and can be legally added. Pure synthetic tripeptide, non animal source, high safety, and minimal side effects.
5、 Application Fields and Market Supply
Palmitoyl tripeptid-8, as a classic anti-inflammatory and soothing peptide material, has a wide range of applications in the sensitive muscle care market.
Research and development background: Palmitoyl tripeptid-8 is a synthetic biomimetic peptide designed based on alpha melanocyte stimulating hormone (α - MSH). Alpha MSH originates from pre melanocortin precursor (POMC) and is a natural anti-inflammatory regulatory factor in the human body. Palmitoyl tripeptid-8 retains high affinity for α - MSH and MC1-R receptors, but has almost no melanin activity. It focuses on exerting anti-inflammatory and soothing effects and is one of the representative raw materials in the field of "Neurocosmetics".
Product positioning: Palmitoyl tripeptid-8 is a potent anti-inflammatory and soothing peptide that serves as a targeted solution for skin sensitivity and inflammation issues. By simulating the anti-inflammatory mechanism of α - MSH, it inhibits the release of inflammatory factors from the source, rapidly relieving sensitive symptoms such as redness, burning, and stinging of the skin.
Market outlook: The global market for sensitive skin care continues to grow, with over 50% of adults experiencing allergic skin problems. Palmitoyl tripeptid-8, as a clinically validated anti-inflammatory and soothing peptide, has broad application prospects in sensitive muscle repair, medical post care, daily stability maintenance, and other scenarios. Its synergistic anti sensitization scheme with peptides such as acetyl tetrapeptide-15 has become one of the mainstream solutions for sensitive muscles in the industry.
