Acetylheptapeptide-4

1、 Product basic file

Chinese name: Acetylheptapeptide-4

English name: Acetyl Heptapeptide-4

CAS number: 868844-72-8

Molecular formula: C ∝₇ H ₆₅ N ₁₅ O ₁∝ S

Molecular weight: 960.08 g/mol

Amino acid sequence: Ac Glu Glu Met Gln Arg Arg Ala (AC EEMQRRA)

Amino acid composition: It consists of seven amino acids: glutamic acid (Glu) × 2, methionine (Met), glutamine (Gln), arginine (Arg) × 2, and alanine (Ala). The N-terminus is acetylated to enhance stability

Appearance specifications: White to off white solid powder, purity usually ≥ 95% (HPLC)

Solubility: Good water solubility

Storage conditions: Powder state sealed and protected from light, frozen at -20 ℃ for 3 years; After preparing the solution, store it at -80 ℃ for 1 year to avoid repeated freezing and thawing

2、 Core efficacy and mechanism of action

Acetylheptapeptide-4 is a synthetic heptapeptide that focuses on the balance of skin microbiota, inspired by the healthy microbiome characteristics of the skin during close contact between human ancestors and nature. The modern urban lifestyle has led to a decrease in the diversity of skin microbiota, causing issues such as sensitivity, irritation, and inflammation. Acetylheptapeptide-4 reconstructs the skin defense system from the "microecological" dimension by simulating the balance mechanism of the natural microbiome. Its core efficacy and mechanism of action are mainly reflected in the following dimensions:

Regulating skin microbiota balance (core efficacy): Acetylheptapeptide-4 can promote the proliferation of beneficial bacteria on the skin, inhibit the excessive proliferation of harmful bacteria, and restore the diversity and balance of the skin microbial community. In vitro experiments have confirmed that acetylheptapeptide-4 can enhance the vitality of skin probiotics, improve skin immune response, and enhance the skin's own defense system.

Enhancing the physical barrier function of the skin: Acetylheptapeptide-4 can enhance the adhesion between keratinocytes, strengthen intercellular connections, and improve the integrity of the skin barrier. Clinical tests have shown that the use of acetylheptapeptide-4 reduces the shedding of keratinocyte scales by 18.6%, indicating significant repair of the skin barrier and aiding in the recovery of sensitive skin to a healthy state.

Significantly reduce transcutaneous water loss (TEWL): clinical tests show that after the use of the face cream containing 0.005% acetylheptapeptide-4, the transcutaneous water loss is reduced by 27%, which proves that it can effectively protect the skin physical barrier, prevent dehydration, and maintain the skin moist state.

Moisturizing and Soothing: As a moisturizer, Acetylheptapeptide-4 has excellent moisture absorption and moisturizing ability, which can help the skin maintain a hydrated environment. At the same time, by balancing the microecology and repairing barriers, it indirectly achieves anti allergic and soothing effects, reducing sensitive symptoms such as skin redness, stinging, dryness, and peeling.

Enhancing skin immunity: Acetylheptapeptide-4 can promote the skin's immune response to harmful bacteria, prevent infections and inflammatory skin problems, and establish a stronger "biological shield" for the skin.

3、 Recommended addition ratio and application scenarios

Acetyl heptapeptide-4 formula has good compatibility and can be added to essence liquid, face cream, lotion, facial mask, facial cleanser, hand sanitizer and other formulations.

Recommended addition ratio:

Pure peptide active concentration: 0.005% (clinically validated effective concentration)

Recommended concentration of commodity solution: Calculated based on the concentration of commodity solution, usually 1% to 5%

Sensitive Skin Repair Products: As a core micro ecological regulatory ingredient, targeting urban sensitive skin, seasonal sensitivity, barrier damage and other scenarios, by restoring microbial balance and strengthening physical barriers, it improves skin sensitivity problems from the root.

Moisturizing and repairing face cream/lotion: use its ability to moisturize and reduce TEWL, apply it to daily moisturizing care products, and help skin maintain the state of moisture barrier.

Microecological skincare products: As the core active ingredient of the "skin probiotics" concept, it is applied in high-end skincare products that emphasize the concept of microecological balance. It works in synergy with prebiotics, prebiotics, and other ingredients to build a complete microecological skincare solution.

Hand sanitizer/body cleansing products: Utilizing their significant prebiotic effects, added to hand sanitizer, restore the healthy microbiome balance of hand skin, replenish moisture, and provide natural protection while cleaning.

Medical art post repair products: utilizing their ability to repair barriers and enhance immunity, applied to medical art post skin repair and care, helping damaged skin quickly recover to a healthy state.

4、 Formula recommendations and safety compliance

Gold synergy combination:

Compound with Caprylglycerol: Caprylglycerol itself has antibacterial and moisturizing functions, and when combined with acetyl heptapeptide-4, it can further strengthen the skin barrier and maintain microecological balance.

Combined with ceramide: Acetylheptapeptide-4 repairs barriers from a microecological perspective, while ceramide repairs barriers from a lipid perspective, achieving a more comprehensive barrier repair effect through both internal and external modifications.

Compound with hyaluronic acid: Acetylheptapeptide-4 is responsible for microbial balance and barrier repair, while hyaluronic acid provides immediate deep moisturizing. The two work together to achieve long-lasting hydration.

In combination with anti-inflammatory and soothing peptides (such as palmitoyl tripeptid-8), acetyl heptapeptide-4 prevents sensitivity from the micro ecological and barrier dimensions, while palmitoyl tripeptid-8 inhibits sensitivity responses from the inflammatory factor dimension, forming a dual anti sensitivity regimen of "prevention+treatment".

Compound with prebiotics/prebiotics: Construct a complete "microecological skincare" system, using acetyl heptapeptide-4 as a "prebiotic peptide" to promote the growth of beneficial bacteria, combined with other prebiotics (such as oligofructose, inulin) and prebiotics (such as lactic acid bacteria fermentation products), to achieve multi-level microecological regulation.

Compatibility and process suggestions: Acetylheptapeptide-4 has good water solubility and is compatible with most water-based formulations. It is recommended to add it at the post formulation stage and under low temperature conditions to preserve its biological activity to the greatest extent possible. The recommended pH range is between 5 and 7.

Safety compliance: Acetylheptapeptide-4 is a pure synthetic heptapeptide, non animal derived, with high safety and minimal side effects. It has been included in the cosmetics raw material database and meets the regulatory requirements for cosmetics both domestically and internationally.

5、 Application Fields and Market Supply

Acetylheptapeptide-4, as a representative active peptide material in the field of "microecological skincare", has broad application prospects in the sensitive skin care and barrier repair market.

Research and development background: The inspiration for the development of acetylheptapeptide-4 comes from an important scientific discovery - human skin living in urban environments will lose some normal microbial communities, leading to sensitivity, irritation, and other inflammatory problems; People who have close contact with nature have a more diverse skin microbiome and more effective defense systems. Acetylheptapeptide-4 aims to promote the balance and diversity of the microbial community, bringing the microbiome of urban skin closer to a healthy state.

Product positioning: Acetylheptapeptide-4 is a skin microbiota regulating peptide. As a "prebiotic peptide", it promotes the proliferation of beneficial bacteria, enhances skin immune response and physical barrier integrity, and reconstructs the skin defense system from the perspective of microbiota. It is one of the core ingredients of the "Microbiome Skincare" concept.

Clinical verification: female volunteers used a face cream containing 0.005% acetylheptapeptide-4, and applied it to the elbow fossa twice a day in the morning and evening. Seven days later, samples of the skin microbial group were tested. The results showed that the bacterial diversity increased significantly, the microbial group reached a better balance, and the skin was healthier. At the same time, transdermal dehydration decreased by 27%, and keratinocyte scales decreased by 18.6%.

Market prospects: With the rapid rise of the concept of "micro ecological skincare" in the global market, acetyl heptapeptide-4, as a pioneering raw material in this field, is expected to continue to increase market awareness and application proportion. Its unique positioning as a "prebiotic peptide" gives it a differentiated competitive advantage in niche markets such as sensitive muscle care, barrier repair, and medical post care.