Oligopeptide-34

1、 Product basic file

Chinese name: Oligopeptide-34

English name: Oligopeptide-34

CAS number: 2227218-62-2

INCI Name: OLIGOPPEPTIDE-34

Molecular formula: C ₆₄ H ₉₄ N ₁₈ O ₂₂

Molecular weight: approximately 1467.57 g/mol

Amino acid composition: Contains 13 types of amino acids, including arginine (Arg), aspartic acid (Asp), glutamine (Gln), serine (Ser), tryptophan (Trp), isoleucine (Ile), leucine (Leu), threonine (Thr), etc

Appearance specifications: White to off white solid powder, purity usually ≥ 95%~98% (HPLC)

Solubility: Water soluble

Storage conditions: sealed and away from light, freeze-dried at -20 ℃, with a shelf life of at least 24 months; Avoid repeated freezing and thawing after preparing the solution

2、 Core efficacy and mechanism of action

Oligopeptide-34 is a synthetic oligopeptide known as the "most effective non hydroquinone skin whitening agent", with multiple anti-inflammatory and anti-aging effects. Its core efficacy and mechanism of action are mainly reflected in the following dimensions:

Powerful whitening and inhibition of melanin synthesis (core efficacy): Oligopeptide-34 synergistically inhibits melanin production and deposition through multiple pathways:

Downregulate key enzymes and transcription factors: Downregulate the expression of TRP-1, TRP-2, MITF (microphthalmic transcription factor), and tyrosinase, reducing melanin synthesis from the source.

Blocking melanosome transfer: blocking the assembly of melanosomes and their transfer from melanocytes to keratinocytes, and cutting off the pathway for melanin to be transmitted to epidermal cells.

Activate MSH decomposition: Activate the decomposition of melanocyte stimulating hormone (MSH), which is the core regulatory factor for tyrosinase production, thereby indirectly inhibiting the cascade reaction of melanin synthesis.

Experimental data: In vitro experiments showed that the addition of oligopeptide-34 reduced melanin production by approximately 33% and tyrosinase activity by 65% in test tubes. In a comparative study with vitamin C (reducing pigmentation by 27%) and arbutin (reducing pigmentation by 40%), oligopeptide-34 reduced pigmentation by 47%, significantly better than both.

Anti inflammatory and Soothing: Due to the downregulation of TH1 pro-inflammatory cytokines, oligopeptide-34 can reduce the proliferation of dermal lymphocytes, produce significant anti-inflammatory effects, and help alleviate skin problems such as post inflammatory pigmentation (PIH).

Anti aging and promoting skin repair: Oligopeptide-34 can promote the division and differentiation of fibroblasts, significantly increase the levels of collagen, elastin, and fibronectin in the extracellular matrix (ECM) of the skin, thereby improving skin firmness and elasticity, and exerting anti-aging effects.

Brightening skin tone and improving skin quality: By inhibiting melanin synthesis and accelerating metabolic renewal of melanocytes, oligopeptide-34 can significantly brighten skin tone, improve dullness, pigmentation, and uneven skin tone.

3、 Recommended addition ratio and application scenarios

The oligopeptide-34 formula has good compatibility, and can be added to essence liquid, face cream, lotion, facial mask, body milk and other formulations.

Recommended addition ratio:

Powder purity: ≥ 95% (HPLC)

Solution concentration: 0.05% (commercial solution)

Specific dosage: It is recommended to determine based on the concentration of the product solution and the formula requirements. It is usually added in the later stage of the formula and at temperatures below 40 ℃ to maximize the retention of peptide activity

Whitening and spot lightening essence/face cream: as the core whitening active ingredient, it uses its ability of multi target inhibition of melanin synthesis to create efficient whitening products for the problems of spots, dullness and uneven skin color.

Anti inflammatory repair products: Utilizing their ability to resist inflammation and promote ECM repair, they are applied in scenarios such as post inflammatory pigmentation (PIH) repair and sensitive skin whitening.

Anti aging and whitening products: Utilizing their dual effects of whitening and anti-aging, applied to mature skin whitening products, while improving pigmentation and wrinkles.

Body whitening products: applied to body lotion, etc., to improve pigmentation and uneven skin tone of the body's skin.

4、 Formula recommendations and safety compliance

Gold synergy combination:

Combined with vitamin C: oligopeptide-34 inhibits the melanin synthesis pathway at the genetic level, while vitamin C exerts its effects at the antioxidant and melanin reducing levels. The two work together to achieve a more comprehensive whitening effect.

Combined with Nonapeptide-1: As an MSH receptor antagonist, Nonapeptide-1 complements the MSH decomposition activation mechanism of oligopeptide-34, synergistically inhibiting melanin production from different targets.

Compound with Tetrapeptide-30 (Brightening Peptide): Construct a multi-target whitening system that covers multiple key stages of melanin synthesis.

Compound with Niacinamide: Niacinamide exerts whitening effects by inhibiting melanosome transfer, and forms upstream downstream synergy with oligopeptide-34 in inhibiting melanin synthesis mechanism.

Compound with hyaluronic acid: oligopeptide-34 is responsible for whitening and anti-aging, while hyaluronic acid provides instant moisturizing and filling, both internally and externally.

Compatibility and process suggestions: Oligopeptide-34 has good water solubility. It is recommended to add it in the later stage of the formula when the temperature is below 40 ℃ to avoid high temperature causing peptide inactivation. Seal and freeze when not in use, and use as soon as possible after opening to avoid secondary microbial contamination.

Safety compliance: Oligopeptide-34 is a pure synthetic oligopeptide, not of animal origin, with high safety and minimal side effects. It has been included in the cosmetics raw material database and meets the regulatory requirements for cosmetics both domestically and internationally.

5、 Application Fields and Market Supply

Oligopeptide-34, as one of the most effective non hydroquinone skin whitening agents, has a wide range of applications in the global whitening and skincare market.

Research and development background: Oligopeptide-34 (CG-TGP2) is a synthetic oligopeptide developed by Genelab, inspired by in-depth research on the melanin synthesis pathway. It simulates natural regulatory factors and simultaneously inhibits the generation, transport, and deposition of melanin from multiple key links, achieving significant whitening effects while also possessing multiple anti-inflammatory and anti-aging effects.

International brand application: Oligopeptide-34 has been adopted by multiple internationally renowned skincare brands, including:

Dermatology: C-12 Pure Bright Serum, Pure Light SPF 50, Pure Night and other products

Lamelle: Brighter Concentrate, Luminess series (Brightening Defense 30, Radiant Eye Cream, etc.)

La Clinica: Brightening Serum series, Vitamin C Ultra Serum, etc

Evidens De Beauté：The Brightening Serum

Neostrata：Enlighten Illuminating Serum

Beaut é Pacifique: Superbruit Collection

PEACE OUT：Dark Spots Serum

Theraskin：Klassis TX+、Klassis ®  Specialle and others

Market prospects: The global whitening and skincare market continues to grow, and consumers have a strong demand for safe and efficient whitening ingredients. As a representative of non hydroquinone whitening agents, oligopeptide-34 has broad application prospects in the market segments of whitening essence, spot lightening products, even skin products, etc., due to its outstanding performance in inhibiting melanin synthesis (significantly better than vitamin C and arbutin), and its multiple effects of anti inflammation and anti-aging.