Other Name: Biotinyl-GHK tripeptide,Bio-GHK

Molecular Weight: 566.67

Appearance: White powder

Purity: >99%

Package: 100G/bottle; 500G/bottle; 1kg/bottle

Biotinoyl Tripeptide-1 is a tripeptide that combines vitamin H with the Matrix series GHK.

Biotinoyl Tripeptide-1 has the effect of increasing the synthesis of extracellular matrix such as collagen IV and laminin 5, 

delaying hair follicle aging, and improving hair follicle structure; Beneficial hair is fixed in the dermal hair follicles to prevent hair loss; 

Activating the expression of tissue repair genes is beneficial for skin structure reconstruction and repair; Promote cell proliferation 

and differentiation, stimulate hair growth.

★What is Biotinoyl Tripeptide-1 and how is it different from other peptides?

Biotinoyl Tripeptide-1 (CAS: 299157-54-3, also known as Bio-GHK) is a unique peptide-biotin conjugate. Unlike Matrixyl (anti-wrinkle) or 

Tetrapeptide-30 (brightening), it features a dual mechanism targeting both hair growth (follicle anchoring via Collagen IV and Laminin V) 

and skin anti-aging (ECM remodeling via the GHK backbone). This makes it ideal for hair serums, eyelash products, and scalp care—

markets that other peptides do not address.

★How does Biotinoyl Tripeptide-1 promote hair growth?

It works through three pathways: first, follicle anchoring—stimulating Collagen IV and Laminin V synthesis to strengthen hair root attachment; 

second, stem cell activation—activating the Wnt/β-catenin signaling pathway to prolong the anagen (growth) phase; third, antioxidant protection—

reducing oxidative stress on hair follicle stem cells. Clinical data shows a 32% reduction in hair shedding after 28 days.

★Is Biotinoyl Tripeptide-1 more effective than Minoxidil?

Yes, comparative studies show superior hair retention and comparable or better growth promotion, with zero side effects (Minoxidil can cause 

scalp irritation and unwanted facial hair). Biotinoyl Tripeptide-1 works physiologically (rebuilding follicle anchors) rather than pharmacologically 

(vasodilation), making it an ideal Minoxidil alternative for long-term cosmetic use.

★Can it be used in eyelash and eyebrow serums?

Yes—this is one of its most popular applications. It prolongs the anagen phase of vellus hairs, delivering visible lengthening and thickening 

without the prostaglandin-related side effects (iris darkening, eye irritation) of prescription lash drugs. It is an ideal choice for clean beauty 

compliant lash serums.

★What is the recommended dosage for different formulations?

It is highly potent at very low concentrations: Leave-on hair serums: 0.001%–0.01% (10–100 ppm); Shampoos/conditioners: 0.01%–0.05%; 

Eyelash serums: 0.001%–0.005%; Scalp treatments: 0.005%–0.02%. Clinical efficacy has been demonstrated at just 10 ppm.