Other Name: Melitane; Melanostatine-5

Molecular Weight: 1206.5

Appearance: White powder

Purity: >98%

Package: 100G/bottle; 500g/bottle; 1kg/bottle

*Nonapeptide-1 (also known as Melanostatine-5) is a proprietary peptide originally developed for its antibacterial activity.

However, animal studies have shown that melitane can inhibit the synthesis of melanin,which makes it important in the 

treatment of certain skins. condition.Animal models show that melitane gel can reduce the synthesis of melanin and 

reduce skin pigmentation in a large extent.Nonapeptide 1 skincare products uased as whitening agent can play a role 

in the early stage of skin darkening mechanism.Nonapeptide-1 can prevent further activation of tyrosinase, thereby 

preventing the synthesis of melanin,so as to better control skin tone and brown spots.Melitane for grey hair treatment 

in cosmetics application.

★What is the approved safe usage concentration in China?

China NMPA data shows maximum historical usage: 2% for leave-on products (full body) and 2% for eye area (leave-on) . 

These concentrations are considered safe for cosmetic use.

★What is the recommended dosage for formulations?

Recommended usage is 5 to 25 ppm (0.0005% – 0.0025%) of active peptide powder. For best results, add during the 

cooling phase below 40°C at pH 5.0-7.0.

★What is the mechanism behind its skin brightening effect?

It competitively binds to MC1 receptors on melanocytes, preventing α-MSH from activating the melanin synthesis cascade. 

This downregulates tyrosinase, TRP-1, and MITF gene expression.