Dipeptide Diaminobutyroyl Benzylamide Diacetate (SYN-AKE)

1、 Product basic file

Chinese name: Snake Venom Tripeptide (also known as Snake Venom Peptide, Dipeptide Diaminobutyrylbenzylamide Diacetate)

English name: Dipeptide Diaminobutyroyl Benzylamide Dicetate

Business name: SYN-AKE ®

CAS number: 823202-99-9

Molecular formula: C ₁₉ H ₂₉ N ₅ O VNet · 2 (C ₂ H ₄ O ₂)

Molecular weight: 495.58 g/mol

Amino acid sequence: {β - Ala} - Pro - {Dab-NHBzl}

Appearance specifications: White to off white solid powder, purity usually ≥ 98%

Solubility: Good water solubility (maximum 10.0 mg/mL); Soluble in DMSO (maximum 3.0 mg/mL)

Storage conditions: Sealed and protected from light, frozen at -20 ℃

2、 Core efficacy and mechanism of action

SYN-AKE ® It is a patented synthetic tripeptide developed by the Swiss company Pentapharm (later acquired by DSM Firmenich), inspired by the Waglerin-1 protein in the venom of the Malaysian Temple Viper. It won the Swiss Technology Award in 2006. Its core efficacy and mechanism of action are mainly reflected in the following dimensions:

Botulinum toxin anti wrinkle (core efficacy): SYN-AKE ® It is an antagonist of the muscle nicotinic acetylcholine receptor (mnAChR), which reversibly blocks the transmission of nerve impulses to facial muscles by simulating the mechanism of action of Waglerin-1. When mnAChR is blocked, the ion channel remains closed, Na ⁺ cannot flow in, and muscle cells remain relaxed, thereby reducing dynamic and expression lines caused by repeated contractions of the expression muscles.

Significant wrinkle reduction effect: In vitro experiments have shown that, SYN-AKE ® Can reduce muscle contraction frequency by up to 82%; Clinical tests have confirmed that after 28 days of use at a concentration of 4%, the depth of crow's feet (Ra, Rz, Rt values) significantly decreases, and the skin surface becomes smoother and more uniform.

Rapid onset, long-lasting and reversible: The effect is rapid, long-lasting and completely reversible, reducing wrinkles on the face in a relaxed state without affecting normal expression, which is different from the "mask face" problem that may be caused by injection of botulinum toxin.

Antioxidant activity: Recent studies have shown that, SYN-AKE ® It has dose-dependent antioxidant activity, and DPPH free radical scavenging experiments have confirmed its antioxidant capacity, providing additional anti-aging protection for the skin.

Preventive anti-aging: New study confirms earlier use of SYN-AKE ®， The more effective it is in delaying the appearance of wrinkles, the more it has a "frozen age" effect, which is suitable for young consumers as a preventive anti-aging measure.

3、 Recommended addition ratio and application scenarios

SYN-AKE ® The formula has good compatibility and can be added to most formula types, including essence liquid, face cream, lotion and water-based products.

Recommended addition ratio: 1% to 4% (based on the product solution). The content of general snake venom peptide facial mask products is about 4%; Eye cream products can be selected with a concentration of 2% to 4% according to their positioning.

Anti wrinkle and firming essence/face cream: as the core active ingredient, it carries out precise light line care for expression lines such as eyebrow lines, decree lines, head lifting lines, puppet lines, etc., focusing on the concept of "smearing botulinum toxin".

Eye care products: applied to eye creams, eye masks, etc., utilizing their significant wrinkle reducing ability to effectively improve crow's feet and dynamic wrinkles around the eyes. Brands such as IMAGE have launched SYN-AKE products ® The series of eye cream products.

Anti aging facial mask: Snake venom facial mask is SYN-AKE ® The classic application form, combined with moisturizing ingredients such as hyaluronic acid and glycerin, achieves instant tightening and lifting effect.

Preventive anti-aging products: targeting young consumers aged 25 and above, focusing on the concept of "frozen age" to prevent facial expressions from solidifying into static patterns.

4、 Formula recommendations and safety compliance

Gold synergy combination:

Compound with Acetyl Hexapeptide-8 (Argireline): Both belong to the "botulinum toxin like" peptide, but have different targets of action (SYN-AKE) ® Targeting mnAChR and Argireline targeting SNAP-25 synergistically block neuromuscular signaling, achieving a more comprehensive anti wrinkle effect.

Compound with red ginseng polyphenols/antioxidant components: Red ginseng polyphenols reduce free radical damage by activating antioxidant pathways and interact with SYN-AKE ® The synergistic formation of antioxidant activity comprehensively combats skin aging.

Compound with hyaluronic acid: SYN-AKE ® Responsible for relaxing muscles, fading dynamic lines, providing instant moisturizing and filling with hyaluronic acid, and achieving both internal and external nourishment.

Compatibility and process suggestions: SYN-AKE ® It is an aqueous solution (glycerol based) that is compatible with most water-based formulations. It is recommended to add it at the post formulation stage and under low temperature conditions to preserve its biological activity to the greatest extent possible. It is recommended to use it within 3 months after opening to prevent the ingredients from becoming inactive.

Security Compliance: SYN-AKE ® Pure synthetic tripeptide, non animal source, meets vegan friendly standards, and has no preservatives. It has been included in the EU CosIng database and its security has been widely recognized by the market. Allergens should use with caution, and patch testing is recommended before use.

5、 Application areas and brand usage display

SYN-AKE ® As the world's most well-known synthetic snake venom tripeptide raw material, it is widely used in the high-end anti-aging skincare market.

Research and Development Background: Developed by Swiss company Pentapharm and awarded the Swiss Technology Award in 2006; In 2007, it was fully acquired by the Royal Dutch DSM Group (DSM); Currently affiliated with DSM Firmenich, it is a benchmark product in the global anti-aging peptide field.

International brand applications: Peter Thomas Roth's Un Wrinkle series, BM LAB snake venom eye cream, etc. are all SYN-AKE ® As the core ingredient, it focuses on the concept of "botulinum toxin" applied anti wrinkle. Since 2010, Hollywood celebrity skin clinics have started recommending SYN-AKE ® Product, Gwyneth Paltrow and other celebrities have become loyal users.

Domestic brand application: SYN-AKE ® It has been widely used in products of domestic and foreign brands such as L'Oreal, Hanshu, Yushen, Guangzhou Ciya, Baiyunshan Group, and IMAGE, and is widely used in functional eye masks/eye creams and anti-aging skincare products.