Papaya fruit extract (Papaya, ext.)
Carica papaya L. fruit extract is a natural plant extract extracted from the fruit of Carica papaya L., widely used in the fields of cosmetics, food, and medicine.
Basic Properties
CAS number: 84012-30-6
EINECS number: 281-675-0
Appearance: usually light yellow to brown powder or liquid
Odor: Characteristic orange flavor (Citrus aroma type)
Molecular formula/molecular weight: a mixture without a fixed molecular formula and molecular weight
Solubility: soluble in solvents such as water and ethanol
Main chemical components:
Papain - Core Active Ingredient
Papain
Rennin (rennin)
Multiple vitamins (A, B ₁, B ₂ C、K）
Minerals (calcium, potassium, magnesium, copper, etc.)
Carotenoids (β - carotene, cryptoxanthin, tomato hydrocarbons, etc.)
Carbohydrates (sucrose, invert sugar), pectin, small amounts of organic acids (tartaric acid, malic acid)
main purpose
Cosmetics/Daily Chemical Industry (Main Applications)
This is the core application area of the extract, labeled as "skin conditioner" in the cosmetic ingredient list.
Humectant: Helps the skin retain moisture
Skin conditioning agents: improve skin condition
Tonic: Promotes skin vitality
Exfoliation/Rejuvenation: Papain hydrolyzes keratin, softens and removes aging keratinocytes, accelerates skin metabolism, and has the effects of cleansing, softening, lightening pigmentation, anti wrinkle, and inhibiting acne
Common application products: cleanser, facial mask, essence, exfoliating product, whitening product, etc
food sector
Digestive aid: Papain can help with protein digestion and can be used for chronic indigestion and gastritis
Meat tenderizer: softens meat texture through protein hydrolysis by proteases
Nutritional supplement: rich in vitamins and carotenoids, with certain nutritional value
Medical/healthcare field
Antibacterial and antiparasitic: Papain has a certain inhibitory effect on Mycobacterium tuberculosis; Papain can drive away tapeworms, roundworms, and whipworms
Antitumor activity: Research has found that papain has anti-tumor activity against lymphocytic leukemia cells; Papaya leaf extract has inhibitory effect on a variety of cancer cells (cervical cancer, breast cancer, liver cancer, lung cancer, pancreatic cancer, etc.), and has no side effects on normal cells
Trauma repair: Papain can be used for wound debridement with necrotic tissue, enzymatic debridement in chronic otitis media, and burns
Anti inflammatory and antioxidant: possessing certain anti-inflammatory and free radical scavenging abilities
Auxiliary hypoglycemic effect: research shows that it has inhibitory effect on type II diabetes related enzymes
safety
GHS classification: No hazard classification found, no hazard statement
Toxicity: Oral/dermal/inhalation toxicity has not been determined (high safety)
Attention: Papain is an effective antigen and may cause allergic reactions; Intravenous injection has high toxicity
Cosmetic use: not recommended for essence or perfume
Summary
Dimension Description
Source: Carica papaya L. fruit extract
Core active ingredient Papain
Main application areas: cosmetics (skin conditioning, exfoliation, moisturizing)
Secondary application areas include food (digestive aid, tender meat), medicine (antibacterial, anti-tumor, wound repair)
Application of extracts from muscovy fruits and melons in the field of veterinary medicine
The extract of passion fruit (CAS: 84012-30-6) is currently mainly in the research and application exploration stage in the field of veterinary medicine, and has not yet been widely used as a formally registered veterinary drug raw material like mupirocin and milberoxime. However, its potential in the veterinary field has been confirmed by multiple studies.
Main application directions of veterinary drugs
Poultry anti worm (deworming)
This is currently the most extensively researched direction. A study by Makerere University in Uganda has shown that papaya leaf/fruit extract has a significant insecticidal effect on poultry worm infections (such as Ascaridia galli):
In vitro experiment: A concentration of 0.08 g/mL can cause over 50% of adult chicken roundworms to lose their motility within 5 hours
In vivo experiment: The fecal egg count reduction rate (FECR) was as high as 97.67%, second only to levamisole hydrochloride (98.67%), and significantly better than the traditional drug piperazine citrate (35.67%)
Core active ingredients: Vitamin C (42%), sterols (13%), triterpenoids (6%), among which Vitamin C is believed to enhance the host's anti parasitic immune response
Poultry anti coccidiosis
Research conducted by the University of Togo and the National Agricultural University of Kenya has confirmed that papaya seed extract has a significant in vitro inhibitory effect on poultry coccidiosis (caused by Eimeria spp.):
At a concentration of 75 mg/mL, it can inhibit approximately 74.53% of the sporulation of coccidian cysts
Simultaneously possessing strong antioxidant activity (69.77 mg/g), it helps to enhance the immunity of poultry
Can be used as a natural raw material for developing new anti coccidiosis compound preparations
Taenia prevention and control (oral vaccine carrier)
Papaya has also been explored as a delivery platform for oral vaccines, used to control various zoonotic tapeworm parasites such as Taenia solium and Echinococcus granulosus
Papaya extract itself has a killing effect on various types of parasites (by destroying the cell membrane of the parasite through protease activity, inhibiting energy metabolism, and interfering with nerve signal transduction)
Papaya suspension culture system can serve as a recombinant antigen expression platform for developing low-cost oral vaccines
The cost of each dose of vaccine is about $0.12, which is 85% lower than traditional vaccines
mechanism of action
The insecticidal effect of extracts from muscovy fruits and melons in veterinary medicine is mainly achieved through the following pathways:
Protease activity (papain): destroys parasite cell membrane and protein structure
Alkaloids (Papain): neurotoxic to parasites
Triterpenes/sterols: inhibit mitochondrial function, interfere with insect energy metabolism
Vitamin C: enhances host immune defense ability, synergistically increases efficacy
Summary
Dimension Description
The registration status of veterinary drugs has not been officially registered as veterinary raw materials, and is currently mainly in the research stage
Main research directions: Poultry deworming (worms, coccidiosis), tapeworm prevention and control
Core advantages: natural, low-cost, no drug residue, and less likely to develop drug resistance
Target animals: poultry (chickens), livestock (pigs, cows)
Compared with traditional drugs, the deworming effect is comparable to levamisole and superior to piperazine
Commercialization prospects as a natural alternative to deworming drugs have great potential in the fields of organic farming and antibiotic free farming
