Calcium racemic ketoisoleucine is a calcium salt of an α-keto acid and a ketogenic analog of branched-chain amino acids (BCAAs), widely used in pharmaceuticals, feed additives, and nutritional supplements.

Basic Properties

CAS Number 66872-75-1

EINECS Number 266-505-5

Molecular formula (anhydrous): C₆H₁₂CaO₃

Molecular weight (anhydrous): 172.24

Molecular formula (hydrate): C₁₂H₁₈CaO₆

Molecular weight (hydrate): 298.35

Physical properties: White to off-white crystalline powder with a distinctive odor and a bitter taste.

Solubility: slightly soluble in water and methanol, soluble in alkaline solutions

Stability: Hygroscopic

Storage conditions: Inert atmosphere, room temperature (preferably in a cool, light-free place at <15°C).

Purity specification: ≥98.5% (by chelation titration, calculated as anhydrous substance)

Calcium content: approximately 13.3%

GHS security information

Signal Word: Warning

Risk Statement:

H302: Causes harmful ingestion

H315: Causes skin irritation

H319: Causes severe ocular irritation

H335: May cause respiratory irritation

pharmacological action

Calcium racemic ketoisoleucine is the calcium salt of an α-keto acid analogue of isoleucine.Its core pharmacological mechanism is as follows:

Transamination: In vivo, catalyzed by transaminases, it accepts an amino group and converts into L-isoleucine (an essential amino acid), thereby supplementing amino acids without increasing nitrogen load.

Nitrogen reuse: Utilizing ammonia produced during metabolic processes (nitrogen prior to the urea cycle) to convert it into useful amino acids, thereby reducing the accumulation of nitrogen-containing waste products.

Calcium supplementation: Provided in the form of calcium salts, it simultaneously delivers calcium elements.

main application

Pharmaceutical sector (for human use)

Calcium racemic ketoglutarate is one of the core active pharmaceutical ingredients in compound α-keto acid tablets. This formulation (e.g., Ketosteril®) serves as a classic medication for nutritional therapy in chronic kidney disease (CKD).

Chronic renal insufficiency: Combined with a low-protein diet to delay the deterioration of renal function and reduce the accumulation of uremic toxins.

Amino acid supplementation: Correcting amino acid metabolic disorders and malnutrition in patients with chronic kidney disease (CKD)

Other effects: promoting bone development, restoring muscle function, alleviating post-exercise fatigue, improving sleep quality, and immunomodulation.

Compound α-keto acid tablets typically contain multiple calcium salts of α-keto acids:

Calcium racemic ketoisoleucine (CAS: 66872-75-1)

Calcium ketovaline (CAS: 51828-94-5)

Calcium ketoleucine (CAS: 51828-95-6)

Calciophenylalanine ketone (CAS: 51828-93-4)

Racemic Hydroxy蛋氨酸 Calcium (CAS: 4857-44-7)

Feed additives sector (veterinary/milk animal)

This is the area you should focus on.Calcium racemic ketoisoleucine is used as a nutritional feed additive in animal husbandry:

Promoting growth: By supplementing branched-chain amino acid precursors, it effectively enhances the growth rate of livestock.

Improvement of meat quality: Optimization of muscle protein synthesis to enhance meat texture and quality

Enhance immunity: Improve the disease resistance of livestock and poultry

Improve feed utilization efficiency: Reduce the protein requirement of livestock and poultry, decrease nitrogen emissions, and alleviate environmental pressure.

Reduction of nitrogen load: Compared to traditional protein feeds, calcium α-keto acids do not increase the burden of nitrogen sources and help reduce the nitrogen content in livestock excreta.

sum up

Dimension Description

Drug type: Calcium α-keto acid salt (amino acid precursor)

Primary Clinical Use: Nutritional Therapy for Chronic Kidney Disease (Active Pharmaceutical Ingredient of Compound α-Ketotic Acid Tablets)

Core applications for animals: Feed nutritional additives (promoting growth, improving meat quality, enhancing feed utilization efficiency)

Is it shared between humans and animals? Both human pharmaceuticals and veterinary feed additives fall into this category.